Eye-related side effects
Summary of BLENREP-associated eye-related side effects in DREAMM-7
*Resolution of ocular adverse reactions was defined as being free from any ocular adverse reactions.
†Events reflect bilateral worsening of BCVA.
‡Resolution of visual acuity was defined as 20/25 or better in at least one eye.
§Resolution of corneal examination findings was defined as Grade 1 or better based on the ophthalmic examination findings.
‖At the time of data cut-off (October 7, 2024).
ERSE: Eye-related side effects.
Summary of changes in best corrected visual acuity in patients treated with BLENREP + Vd1
See what each vision change could look like
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20/20 
Baseline visual acuity reference.
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20/50 
Of the patients with a 20/50 BCVA or worse, 93% (78/84) experienced resolution of the first event.1* The median time to resolution of the first event was 63.5 days.1
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20/200 
Of the patients with a BCVA of 20/200 or worse, 80% (4/5) experienced resolution of the first event.1* The median time to resolution of the first event was 86.5 days.1
Images are for illustrative purposes only. Vision will differ for each individual. Images created with an ECP using methodology derived from Hunt & Bassi applying defined Gaussian blur and pixelation. Vision impairment simulation via Adobe Photoshop through application of a fixed Gaussian blur level: 20/20 0.5 pixels; 20/50 4.0 pixels; 20/200 15 pixels.2
*Resolution of visual acuity was defined as 20/25 or better in at least one eye.
†Improved to better than bilateral 20/200.
Summary of BLENREP-associated eye-related side effects in DREAMM-8
*Resolution of ocular adverse reactions was defined as being free from any ocular adverse reactions.
†Events reflect bilateral worsening of BCVA.
‡Resolution of visual acuity was defined as 20/25 or better in at least one eye.
§Resolution of corneal examination findings was defined as Grade 1 or better based on the ophthalmic examination findings.
‖At the time of data cut-off (October 7, 2024).
ERSE: Eye-related side effects.
Summary of changes in best corrected visual acuity in patients treated with BLENREP + Pd1
See what each vision change could look like
-
20/20 Baseline visual acuity reference.
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20/50 Of the patients with a 20/50 BCVA or worse, 88% (45/51) experienced resolution of the first event.1* The median time to resolution of the first event was 57 days.1
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20/200 Of the patients with a BCVA of 20/200 or worse, 80% (4/5) experienced resolution of the first event.1* The median time to resolution of the first event was 86.5 days.1
Images are for illustrative purposes only. Vision will differ for each individual. Images created with an ECP using methodology derived from Hunt & Bassi applying defined Gaussian blur and pixelation. Vision impairment simulation via Adobe Photoshop through application of a fixed Gaussian blur level: 20/20 0.5 pixels; 20/50 4.0 pixels; 20/200 15 pixels.2
*Resolution of visual acuity was defined as 20/25 or better in at least one eye.
†Improved to better than bilateral 20/200.